Understanding IR
I don't know why the blasted notice isn't showing up, but I just put
up a new file: http://f1.grp.yahoofs.com/v1/oLL7Rynr2aUJh77oxOztiMcL0yU9HC8Eub1Hmaetj XlNpX35vApiL1fR74iShf0wvJJcbp8a3Y_7-yXoLd4/CUSHING%27S%20AND% 20INSULIN%20RESISTANCE%2C%20WEEK%203%20%20APPENDIX.pdf File itself is called "Cushing's and Insulin Resistance Week 3 Appendix". It's an excerpt from the Cushing's and IR online course that explains how all the blood/biochemical abnormalities can be traced to one enzyme system. Some background for those not taking the course: Leptin - a hormone produced by fat cells. Horses with IR are also resistant to leptin. Leptin normally turns off appetite and instructs cells metabolically. Adiponectin - another hormone produced by fat cells. Low in IR. It is insulin sensitizing. Adipokines = hormones/messengers produced by fat Cytokines = cellular messengers (adipokines are a type of cytokine) TNF-alpha - an inflammatory cytokine elevated in IR. Eleanor www.drkellon.com
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