Shoni has been on an equiflex supplement with chondroitin, msm,glucosamine for more than 5 years, probably nearer 10 now . We discussed it with the vet and she was happy for us to give this with the pergolide. She also has one bute per day now to keep her comfortable - have tried devils claw and a lot of other things but this is the only thing that keeps her comfortable. The equiflex doesn’t seem to have any effect on making her more or less prone to laminitis. This isn’t scientific - just telling you what we do