Re: Dexamethasone and Laminitis
Eleanor Kellon, VMD
--- In EquineCushings@..., "betsygilaspy" <betsygilaspy@...> wrote:
The connection between corticosteroids and laminitis has been observed for a very long time. However, when researchers tried to induce laminitis with steroids they failed. This led to a long standing debate over whether it was truly a possible side effect of the drugs or just a coincidence.
Corticosteroids induce insulin resistance. When it came to be understood that horses could be IR, vets put 2 + 2 together to postulate that horses which get laminitis after corticosteroids may well be IR to begin with and the drug pushed them over the edge:
However, it doesn't tell you if the horse is only IR or if the IR is secondary to Cushing's/PPID. In PPID, high levels of ACTH cause high levels of the natural corticosteroid, cortisol. You should therefore test for both conditions, especially if the horse is older than 10.
Eleanor in PA