Re: PPID = vaccine reactions?
Eleanor Kellon, VMD
Anecdotally, does PPID and/or pergolide seem to exacerbate vaccine reactions? .......If PPID is unlikely to worsen a vaccine reaction, would the Banamine possibly cause an insulin spike or a temporary worsening of her IR/PPID?
There's no evidence to suggest Banamine could be involved.
Not much equine specific information except for this study:
Evaluation of systemic immunologic hyperreactivity after intraderma... - PubMed - NCBI
There is some information available on IR horses showing an inflammatory cytokine profile compared to non-IR horses. This could certainly lead to exaggerated reactions.
Novel link between inflammation and impaired glucose transport duri... - PubMed - NCBI
while other studies show a mixed bag and definitely differences between horses (and lab animals which react more like human)
Neutrophil and cytokine dysregulation in hyperinsulinemic obese hor... - PubMed - NCBI
When you throw PPID into the mix, it gets even more complicated but long story short is that cortisol shifts the immune system into Th2 mode (antibody mediated, inflammation and allergy) vs Th1 (cellular immunity).
Eleanor in PA