Re: excessive peeing

Kerry Isherwood

So excessive peeing/polyuria is seen commonly in IR as well as PPID bc of the abnormally high glucose in blood (hyperglycemia).
Horses rarely have high glucose levels. Finger can be pointed at high cortisol levels,though.

Good point. But how does high cortisol result in PU/PD in IR-only horses (non-PPID)? Transient stress?

I guess b/c i check my mare's glucose & insulin so often (and she has been repeatedly hyperglycemic) that I was inclined to believe hyperglycemia was spurring the PU/PD. I check it with glucometer at draw and then send out G&I on same sample in a serum tube that isnt always spun right away. Subsequent lab results always show a markedly lowered BG from glucometer results in tubes not spun quickly (from known RBC consumption no doubt). I'm wondering if hyperglycemia isnt more common but undocumented in chronic IRs w severe hyperinsulinemia bc of the typical way ambulatory vets draw blood samples: a single serum tube that sits in the car for hours before getting spun. Its just something Ive been pondering bc I have the overlap with handling diabetic dog & cat blood w immed access to glucometers...but of course we're also talking two distinctly different diabetes mellitus: type I and type II...

Furthermore, my mare was diagnosed PPID shortly after the hyperglycemic episodes so i've sorta invalidated my own argument ;) but perhaps its a good experiment for my 8yo IR gelding with normal eACTH and no PPID symptoms

Kerry in NY
Pinky Sept 2014
Tofurky Nov 2014

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