Here is a post from Jaini that I found in the archives regarding Excede. Post #174118
All should be aware of the potential of cephalosporins, in particular ceftiofur (Excenel, Naxcel, Excede) to cause laminitis.
These drugs are commonly used, and labeled for use in horses - but caution, big-time, should be exercised in their use. In fact, don't use them in horses at all.