Re: Was ACTH and Lyme, Now Reference Range Question
janieclougher@...
Hi, Terri - If Yahoo allowed attachments, you would see a picture of me with my hair on fire, running around and screaming! Here are some links that might help:This
is the Liphook graph that shows PPID horses have much higher seasonal
rise ACTH than normal horses, so that an ACTH of 100 pg/ml means PPID,
not a normal seasonal ACTH: These
two links should take you to the Pergolide Database; there are 75
horses whose dose is 3.0to 10.0 mg; and a further 14 with doses above
10.0 mg (as well as the many, many horses with doses up to 3.0 mg) The
first pages all have case histories attached, so one can review and see
the factors involved, the diets, the horse's status, etc. Not much sign
of "toxicity" there. (I know I am preaching to the choir!) Merlin is on
16 mg (typo in database, must correct that), and at age 34 moves better
than he did at 28, before his initial IR diagnosis (diagnosed PPID at
age 29) https://dl.dropboxusercontent.com/u/24516590/DosageDatabase/ECIR%20Pergolide%20Dosage%20Database.pdf https://groups.yahoo.com/neo/groups/EquineCushings/search/files?query=database The
next two links take you to the Proceedings of the 2013 NO Laminitis!
Conference. You can also get these from the ecirhorse.org webpage, but
showing that the ECIR Group has proceedings on a reputable veterinary
database might help. (unfortunately, none of the papers directly deal
with pergolide dosage) You
are so correct - the consequences of not having PPID controlled, and
Lyme controlled, are devastating. It wasn't too very long ago that PPID
was virtually a death sentence, or at the least a fairly miserable
existence with laminitis every year, because it was just assumed that
that is the progression of the condition. Well, yes, it is the
progression of the untreated, or under-treated, condition, but it no
longer has to be that way. Sorry for the rant. I hope you can get a vet that can help you and your horses.Jaini (BVSc),Merlin,Maggie,Gypsy BC 09 ECIR mod/support http://pets.groups.yahoo.com/group/ECHistory/files/Jaini%20Clougher%2C%20Smithers%20BC/
Is there documentation that will help discussions with the vets? Thanks again, Terri
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