Re: two doses of tramadol for laminitis


Eleanor Kellon, VMD
 


--In EquineCushings@..., <lj_friedman@...> wrote :

i read a blip about 2 doses of tramadol to achieve painrelief with laminitis   do we use tramadol?

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First, if it's the study Kathy found, it's not two doses, it's the effect of two different trial doses.


The higher oral dose reduced weight shifting and was tolerated for a week. There were only four horses.


Problems:


Tramadol is a narcotic.  During use, there is the risk of gut slowing and agitation. Dependency can develop with withdrawal when it is stopped.


This drug also increases concentrations of serotonin in the brain with risk of withdrawal similar to that seen with SSRI tranquilizers.  High serotonin might also make it contraindicated in PPID horses because serotonin is a dopamine antagonist.


Eleanor in PA

www.drkellon.com

EC Co-owner

Feb 2001

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