Hi, Bonnie - there isn't a really good answer to this.  APF certainly can be used as a long-term supplement without danger, but the cost does become a factor. An alternative is to use jiaogulan; it supports nitric oxide production, and improves circulation (always useful in winter), but also acts as an adaptogen. Information about jiaogulan can be found here:  https://ecir.groups.io/g/main/files/Pain%20Medication%20and%20Alternatives/Jiaogulan,%20Nitric%20Oxide%20Support,%20AAKG%20and%20Supps   in the Pain Medication and Alternatives folder:  https://ecir.groups.io/g/main/files/Pain%20Medication%20and%20Alternatives  

I buy mine from My Best Horse:  http://mybesthorse.com/  

There are lots of anecdotes about horses (and donkeys) perking up and feeling much better on the J-herb (although its primary use is to improve circulation to the extremities), and there is good science about the action in the body.
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Jaini Clougher (BSc,BVSc)

Merlin (over the bridge) ,Maggie,Gypsy, Ranger

https://ecir.groups.io/g/CaseHistory/files/Jaini%20and%20Merlin-Maggie-Gypsy