Re: Isoxuprine

Jackie Rice <jrice@...>

When he had the laminitis episode, he was put on Isoxuprine 21 days 2X per day, then 14 days 1X per day, then 7 days every other day. Also Bute 2 gm per day for 5 days and 2 days off. And aspirin powder every other day. We also had pads on his feet until they grew out enough for shoes. Now, he's on cyproheptidine and has had no more laminitis attacks. Managed to keep his coffin bones virtually unrotated.

But, now he's very sore in the hindquarters. The vet and the farrier aren't sure what's going on. Seems NOT to be his feet or his fetlock joints. Maybe in his hocks or hips. His back muscles are not sore. The vet thinks his balance was thrown off by the way he was standing when his front feet were sore.

Anyone had a similar situation? He's very uncomfortable in the hindquarters.

----- Original Message -----
From: glorye@...
To: EquineCushings@...
Sent: Friday, June 30, 2000 10:29 AM
Subject: [EquineCushings] Isoxuprine

Does anyone on the list with a laminitic/foundered Cushing's horse use
Isoxuprine in their management? I'd be interested to hear about it.

My 20-year-old Morgan gelding was diagnosed with Cushing's when he had one
bout of laminitis in January '99. He was immediately started on Isoxuprine at
that time (in conjunction with Cypro, Thyro-L and Bute).

As I understand it, Isoxuprine is a vasodilator, which helps blood flow
return from the hoof up into the leg. Therefore, it's helpful treating

"Bug" was slowly weaned off Isoxuprine in the months following his laminitic
bout, but I keep a bottle on hand and monitor his pedal pulses very
carefully. If he seems to be having a bad day or week, he gets a low dosage
for a couple of days. My vet approves of this, and even encourages me to
place him on a low dosage when he's being slowly introduced to grass in the

Paula Brown
Poland, ME


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