Re: Compounded Pergolide instead of Prascend

Eleanor Kellon, VMD

The confusion arises from a USP monograph on how to prepare liquid pergolide suspensions which calls for 1mg of pergolide mesylate instead of 1 mg pergolide activity.  1 mg of pergolide mesylate is equivalent to about 2/3 mg of pergolide (the rest is the mesylate). Prascend tablets = 1 mg pergolide activity = 1.33 mg of pergolide mesylate.

Compounders use the information in USP monographs to prepare their products so the above recommendation got carried over to the dry formulations as well.

To guarantee your tablets are equivalent to the dosage in a Prascend tablet the prescription should read:

                                   1 mg of pergolide from pergolide mesylate
Eleanor in PA 
EC Owner 2001

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