Re: Moving forward diet, supplement and medication advice
As far as Isox:
From 2002: https://pubmed.ncbi.nlm.nih.gov/12000527/
Clinical trials appear to support the use of isoxsuprine for treatment of navicular disease. However, poor bioavailability, lack of cardiovascular effects following oral administration, superficial support in clinical trials, and new evidence regarding the pathogenesis of navicular syndrome indicate that the use of isoxsuprine for treatment of navicular syndrome or laminitis is questionable at best.
https://aaep.org/sites/default/files/issues/proceedings-08proceedings-z9100108000337.PDF - refers back to studies in 1997 and 1999, same as the 2014 study
From 2014: https://www.dovepress.com/the-management-of-equine-acute-laminitis-peer-reviewed-fulltext-article-VMRR
Medications used to improve digital blood flow (acepromazine, glyceryl trinitrate, and isoxsuprine hydrochloride) do not appear to improve the clinical outcomes of horses with laminitis.
Cinnamon has not been found to be effective in treating laminitis (you can do a search on that in our messages as well).