Re: Adjusting pergolide when base numbers are normal


Eleanor Kellon, VMD
 
Edited

It's actually the distal lobe, pars distalis, that normally produces ACTH under the influence of CRH. CRH secretion is linked to the circulating cortisol level. In the normal, every day function of the median lobe, a tiny amount of ACTH is produced as an intermediary in other reactions https://flipper.diff.org/app/pathways/info/2863 . The median lobe is normally under the control of dopamine. When that control is lost, the levels of all its hormones is increased but ACTH is actually the lowest.

When ACTH from the median lobe shoots too high, it triggers cortisol production just like ACTH from the pars distalis. That increased cortisol then inhibits CRH and ACTH normal production.
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Eleanor in PA

www.drkellon.com 
EC Owner 2001

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