I will admit that his bandying about oxidative stress, a hydraulic system, and Desmosomal bonds, has confounded me for the moment. The first thing that jumped out at me that I knew was an issue however, was matrix metalloproteinase
"First, all swelling involves oxidative stress. Secondly, it creates a hydraulic system. The oxidative stress activates the matrix metalloproteinase. This stress causes the breakdown of the Desmosomal bonds in the lamina if left untreated."
matrix metalloproteinase is a product of laminitis in cases other than metabolic (high insulin) laminitis. MMP occurs in hind gut driven laminitis like feed room break-in, black walnut, systemic inflammation and lamintis via fructan bolus like that done in the early years by Pollitt. The testimonial on their page is a case of feed room break in. https://www.beatlaminitis.com/about
80-90 percent of laminitis cases are caused by metabolic issues, not hind-gut disruption.
Nancy C in NH
ECIR Moderator 2003
ECIR Group Inc. President/Treasurer 2020-2021
Recordings of the 2021 NO Laminitis! Conference released to attendees 09.03.21.
Veterinary Professional CE certification hours submitted to AAVSB Race 09.08.21