Thank you for the response to my question! I have the same philosophy as this group regarding caring for both conditions. This is my husband‘s horse and the vet suggested Metformin straight away. This really has bothered me a lot. The side effects when reading the insert to metformin include G.I. disturbances and kidney side effects. I share this with my husband and he continues to use the Metformin . I will forward the answer you sent and hopefully he will read it and reconsider