Metformin shouldn’t affect the appetite but it can irritate mucous membranes in the mouth—which may put them off food. Have you been rinsing her mouth post-syringing, or mixing the metformin with a buffer such as milk of magnesia? Many members have found this effective. 
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Maxine and Indy (PPID) and Dangles (PPID)

Canberra, Australia 2010
ECIR Primary Response

https://ecir.groups.io/g/CaseHistory/files/Maxine%20and%20Indy%20and%20Dangles 
https://ecir.groups.io/g/CaseHistory/album?id=933