IME, hungry all day is part of uncontrolled IR.

You need to do what you need to do to avoid choke. 

Some members have used large rocks in the feed pan/bucket to slow them down. Psyllium previously mentioned.

Nancy C in NH
ECIR Moderator 2003
Join us at the 2015 NO Laminitis! Conference, Georgetown TX, November 6-8, 2015
 
www.nolaminitis.com

I'll try to get a dialogue going with Dr. Adams.  Time short this week though so please send me an e-mail next Monday and remind me.

Eleanor in PA
www.drkellon.com
EC Co-owner
Feb 2001

Sorry for the partial earlier post.

Dr Kellon, would you consider going direct with the president of the company, who responded to my questions this morning, to ask for the study data? I can provide his email address, and his phone is shown below. Or get the study data from the researchers? The lead researcher in the AQHA financed study was Amanda A. Adams, contact details at http://www2.ca.uky.edu/gluck/AdamsAA.asp   I’m out of my depth with the statistical details, recognizing only that this is a very small study of a short duration.

Answers: No, there were no diet changes, all horses were dry-lotted on hay, and no, neither metformin nor levothyroxine were administered. Control horses received only the yeast as a placebo. The study duration was 45 days in the autumn. The reduction in insulin levels in EMS horses administered Metabarol daily (45 day study duration), versus placebo, was statistically significant at the alpha = 0.05 level. 

In any event I'm unwilling to cut Satra's hay from 1 ¾ %/BW to 1 ½ %. Her grass hay diet hasn't changed significantly since I recognized she was PPID in 2012 or has only become more strict, so the doubling of her insulin within the past 6 months is independent of diet changes. We're working on getting new blood tests done at the same time of day as earlier tests to remove that variable  from the equation.

I take the liberty of copying the email.

----------------------------

Hello Cass,

Thank you for your interest in Metabarol. One thing I would like to point out is that the researchers performing this study used the Scientific Method in designing and executing this study. In keeping with the Scientific Method, the study was designed such that as few variables as possible were modified or changed before and during the study such that there is maximal statistical power in determining if there indeed is a significant effect of an independent variable, which in this case is whether or not an EMS horse received Metabarol or placebo. The dependent variable in this study is the insulin level of the horse or concentration of inflammatory mediators present in the blood. Please see answers to your specific questions below.

Were the diets of the two groups identical before & during the study? 

Yes, the diets of the horses were identical before and during the study. All horses were maintained on a dry lot and fed only hay. The control group also received placebo (yeast, Sacharromyces cerevisiae, carrier in Metabarol) daily, while the treatment group received Metabarol daily. 

Were there diet changes during the study? What time of year? Were Metformin or levothyroxine administered?

The diets were not changed during the study. Changing the diet during the study would introduce a confounding variable. Metformin NOR levoythyroxine were not administered to control or treatment group horses.  The study was designed to determine if Metabarol administration reduced insulin levels in EMS horses. Therefore, there would be no reason to administer Metformin or Levothyroxine. The study was performed in Autumn.

The demonstrated capability of Metabarol to reduce insulin levels in EMS horses IS INDEPENDENT OF DIET. The reduction in insulin levels in EMS horses administered Metabarol daily (45 day study duration), versus placebo, was statistically significant at the alpha = 0.05 level. 

Thanks again for your interest in Metabarol. Have a great day!

Patrick Lawless PhD

President

Biological Prospects LLC

Office

449 Lewis Hargett Circle, Suite 190

Lexington, Kentucky 40503

(P) 866.721.1412

(F) 866.415.6808

Laboratory

University of Kentucky

ASTeCC Building

Room A346

145 Graham Avenue

Lexington, KY 40506-0286

I think I may be not seeing the big picture so let me just ask.....are you giving Naproxen  Sodium on a daily basis or just in special circumstances....i.e. farrier?  Short term for flare ups?  

I don't know that it makes sense for me to ask more questions because yours are so specific. I received a response this morning the president of the company that I am taking the liberty of copying below. 

I did some syringing in to get started, then threw mine in mashed ODTB Cubes and  TCLite, for my gelding with no teeth. 

Nancy C in NH
ECIR Moderator 2003
Please join us at the 2015 NO Laminitis! Conference, Georgetown TX, November 6-8, 2015
EARLY BIRD EXPIRES Wednesday!
NO Laminitis!

Hi Corrine

Please look at the consistency of the cubes when you feed them. My gelding with no teeth successfully ate them  very loose - a mash really -  and by adding psyllium which makes them more slimey and easier to swallow.   It took getting used to.  With slow transition and patience i finally won out and he did great on them.

Also review his dental needs.  The above gelding needed the dentist every six months to keep what he had left as good as possible.

Nancy C in NH
ECIR Moderator 2003
FACT: The VA Polytechnic Pony Study is the only study to look at IR and laminitis under natural conditions. Learn more at the 2015 NO Laminitis! Conference in Georgetown, Texas, November 6-8.
Guest Speakers

 

Discounted registration expires Wednesday, September 23rd.

When: November 6-8, 2015

Where: Georgetown, TX ~ Just outside Austin

When: November 6-8, 2015

Where: Georgetown, TX ~ Just outside Austin
Featured
Speakers : Eleanor M. Kellon, VMD
   
    Robert M. Bowker, VMD, PhD
   
    Kathleen Gustafson, PhD
  
    Philip J. Johnson, BVSc, MS, DACVIM, DECEIM, MRCVS
   
    Lavinia Fiscaletti, BA
   
    Daisy A. Bicking, DEP, APF, CFGP, CLS
   
    Benjamin R. Buchanan, DVM, DACVIM, DACVECC

NO Laminitis!

 

Tickets must be purchased in advance, prior to October 22nd.

There is much work to do and volunteers are dedicating many hours to getting ready. Registering in advance helps organizers plan the best possible event. Thank you to those of you who have stepped up!

The NO Laminitis! conference offers three days of information dedicated to the welfare of the PPID/IR equine and is approved for veterinary continuing education credits by AAVSB/RACE*, as well as by the the United States Dressage Federation for USDF University accreditation.

http://www.usdf.org/calendar/course.asp?CoursePass=102649

A veterinary student discount is also available.

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Thank you to our Benefactors for their generous donations for this major 2015 ECIR Group Inc. fund raising event. Please tell these companies you appreciate their support the next time you talk with them or visit their web site, which you can access while visiting ecirhorse.org or nolaminitis.org.

Diamond Benefactors


California Trace


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Looking forward to seeing you!


The 2015 NO Laminitis! Conference Committee



*This program was reviewed and approved by the AAVSB RACE program for 13 hours of continuing education in jurisdictions that recognize AAVSB RACE approval. Please contact the AAVSB RACE program if you have any comments/concerns regarding this program's validity or relevancy to the veterinary profession. Participants should be aware that some boards have limitations on the number of hours accepted in certain categories and/or restrictions on certain methods of delivery of continuing education. Contact Nancy Collins ecirgroup1@... for further information.


Hi LJ, when I started Monty on Prascend last fall, my target dose was 2gm/day. I split the dose assuming it was better, mainly b/c he'd come off 'bute which was 2x/day and never even thought to ask the vet.  I think it was in one of your posts early last summer that you brought up the subject and through that I learned I'd been dosing wrong, so went to 2gm 1x/day.  

Thanks I will sit down now and figure it out for my mare. How do you get the horse to take these? Can they be syringed? I tried one in a safe cookie but no go.
Sharon
E to
2005

Sent from my iPhone
Please forgive any errors

196660Spring worming for Cushing/ir pony
sandiegharriesSep 17 7:27 AM
Hi.

My pony was recently diagnosed with above, therefore I need to review my wormers.

I've done some reading and I would like to know if I got it right.

As part of spring worming I want to target strongyles and tape worms. I used to use equest + but it has praziquantel and moxidectin :0(

Therefore, is it ok to do equimec (which has ivermectin), than 3 weeks later equimec + tape ( ivermectin and praziquantel), than after 3 weeks equimec again for small strongyles.

Yes or no?
Then, what do I rotate with? What do I do in autumn? I usually worm 2X / year and fec in between. If I need to worm more than that what is recommended to rotate with?

Sandie g harries
Victoria, Australia
Since June 2015

When ivread in this post I see that you were giving the pergolide two times a day. I thought I read from Dr. K that two times a day is never as good as one time a day. So i am wondering why people give their meds two times a day when I'm thinking it should only be given one time a day? LJ Friedman San Diego

In reading this post, I was wondering if renal failure is associated with Cushing's or IR? LJ Friedman San Diego November 2014

Thank you for your thoughts, Nancy. 

Here's the link: