Date
1 - 10 of 10
RePost - high insulin from other sources
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pposey09
Still hoping for a response.... thank you.
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Re-reading the Cornell lab test info. I'm wondering about high insulin from other sources. Has this group encountered cases of high insulin triggered by a disease process or condition other than IR and PPID? |
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Lavinia <dnlf@...>
Has this group encountered cases of high insulin triggered by a disease process or condition other than IR and PPID?Hi Paula, Sorry this wasn't addressed earlier. Yes: exercising before testing; eating within four hours of the test if there was a period of more than 6 hours previous to that with no food; high sugar/starch feeds within 2 hours of the test; diseases such as Lyme; in mares, possible hormonal/reproductive issues can all raise the insulin reading. This is why we recommend quiet barn, no exercise, steady access to low s/s hay before blood draws. This is also why we ask for a case history so that other things that might influence the results can be ferreted out. Lavinia, Dante, George Too and Peanut Jan 05, RI EC Support Team |
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--- In EquineCushings@..., "Lavinia" <dnlf@...> wrote:
Lavinia and all,Has this group encountered cases of high insulin triggered by a disease process or condition other than IR and PPID? I will bump this up again to see if anyone has any knowledge of any particular disorder or disease process or organ issues that might contribute to insulin being high (and continuing to climb) despite measures to diagnose and address PPID & IR. I am thinking specifically of Alison's Diesel, who is experiencing a steady climb in his insulin levels despite a good eACTH and what would seem to be well-controlled IR. He has no observable signs of IR (no hard neck crest, fat pads, puffy sheath, etc.) but he continues to be sore, off and on. His diet is tightly controlled and his comfort is always seen to--boots, fans, etc. Alison has been really careful to follow protocol with his blood draws, and his trims are not always perfect, but they are MUCH improved and she really stays on top of them. I apologize for not linking to his case history (Alison, Diesel, TX) but he recently underwent a second eye cancer surgery and cisplatin treatment, which I think Dr. K thought might possibly have some bearing on his condition. So, to summarize, are there any known specific conditions or organ dysfunctions that would cause insulin to continue to rise if ACTH and glucose appear to be well controlled and the horse is on a tight diet, with a good trim? Lisa in TX Pookey Bear June 2010 |
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pposey09
Thank you Lavina. I recently found in the info you include below about non-fasting in an article or post by Dr. K. Now, I can't find my way back to that info and it was really good. Can you direct me back that info?
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My testing has been non-fasting, but I fed as usual late evening...about 5 lbs of hay(of the 18 lbs she gets per day). Even in a net, not enough to last all night. Provided hay at the usual time in the morning and pulled blood within an hour or two. My guess is she had been 6 hours with no hay by the time I fed in the am. So, are we saying here to provide enough hay to last all night, even if that means feeding more than usual? For her, this is not diagnostic. I just need readings that are as consistent as possible. The emphasis has been on the ACTH value on the tests. But, I need to have a good insulin number to know if the pergolide dose and the ACTH value reflected by that dose is affecting insulin. I have the impression high cortisol is a pathway elevating insulin. Is this correct? I'll find the link to her file and attach it to another post. Again, thank you! Paula, MT 12/09 In EquineCushings@..., "Lavinia" <dnlf@...> wrote: Has this group encountered cases of high insulin triggered by a disease process or condition other than IR and PPID?Hi Paula, |
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pposey09
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I'll find the link to her file and attach it to another post. |
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pposey09
I need opinions before I test. Bottom line questions: For a test at 8am, do I feed hay, in addition to her usual 5 lbs that lasts 1.5 hours in a net, the evening before we test? I usually feed between 10pm and midnight.
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Do I give hay in the am, as usual at 6:30am, before her test? Based on the info below (and what I read by Dr. K that I can't find again)I think not. Or, is better to test at a different time of day? For example, remove hay at 9am and test at 1pm? Or, for my purposes, would it best to go back to the other standard which I believe is a flake of hay at 10pm and draw blood in the am before feeding anything? Again, I just need a method that can be consistent and comparable to a standard. I understand the poly tech way is a ratio of her numbers. But we do compare that ratio to others. So, I need to be sure I'm operating within the protocol. I appreciate your help because I really am not clear. Sadly, I'm a very linear thinker ... please bear with me. Paula, MT 12/09 Thank you Lavina. I recently found in the info you include below about non-fasting in an article or post by Dr. K. Now, I can't find my way back to that info and it was really good. Can you direct me back that info? In EquineCushings@..., "Lavinia" <dnlf@> wrote:Has this group encountered cases of high insulin triggered by a disease process or condition other than IR and PPID?Hi Paula, |
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gypsylassie
--- In EquineCushings@..., "pposey09" <pposey@...> wrote:
Hi Paula, Not an expert at all, but my "layman's" way of thinking of the" feeding for the test" thing is this. If time has gone by since they last ate, then the next meal (talking hay here) will set off an insulin surge that will effect results for 4 hrs. So if they can't have 24/7 hay, I think it would be, as an example: feed their hay at 7:00 am then wait 4 hours for the test, and I think it's ok if they have hay during that 4hrs. No grains etc. before the test (which these guys don't get grain) but I'd have to go to the files for the protocol on meds etc. I think that's it, please someone correct me if I flubbed it. Thanks. My boy freaks out over needles so we've just diag IR on symptoms so far, but I really do need to get him tested too, so I know exactly where we stand. Laura K. Chappie & Beau N.IL.2011 http://pets.groups.yahoo.com/group/ECHistory5/files/Laura%20K.%20%26%20Chappie/ |
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Hi Lisa
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Would add Iron overload to Lavinia's list which needs to be confirmed via blood test at KSU. Also check Dr Kellon's recent response to IR worsening with age. <http://pets.groups.yahoo.com/group/EquineCushings/message/169611> Recommend this link also regarding Dr Kellon's gelding protocol. <<http://pets.groups.yahoo.com/group/EquineCushings/message/167492>> Nancy C in NH ECIR Moderator 2003 NewEnglandEquineBalance@... --- In EquineCushings@..., "lonestarquarterh" <mostlyaggies@...> wrote:
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kenlynnenagaha@...
Hi All,
I am just catching up on my email and thought I would add in my experience in the transition from pergolide to Prascend. The transition has gone very smoothly. The only difference I can see from the compounded pergolide to the Prascend, is that her heat cycles are more pronounced. Before you could tell she was in season because she might flash her tail a little, but now she is a regular Vamp!! Giving everybody the "come hither" look. She takes her tablet with a little handful of hoof supplement every morning and not once has turned away from it. So all has gone very well. The one bummer is the cost. It is more then double in price. Hopefully in the future the price will come down. I'm happy and most importantly, my mare Dani is! Sincerely, Lynne & Dani Paso Robles 2009 |
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painted_trail78
I am just catching up on my email and thought I would add in my experience in the transition from pergolide to Prascend. The transition has gone very smoothly. The only difference I can see from the compounded pergolide to the Prascend, is that her heat cycles are more pronounced.Hi Lynne, I am curious about your dosages. Did you go from 1mg compounded capsules to 1mg Prascend? Haven't personally had to make the switch because of a cooperative vet and the compounded is so easy to adjust for seasonal rise. Hope all continues to go well for you and your mare, Carol and Casey, Jesse too Yucaipa, CA May 2009 http://pets.groups.yahoo.com/group/ECHistory/files/Carol%20and%20Casey/ |
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