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Prascend and pergolide
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lj friedman
Is it okay to switch between the two meds? For example let's say you had one month of prascend and then next month pergolide? Also if using prascend and knowing that the active ingredient is fixed and more reliable,how can you titrate starting at one quarter and working up to a full 1 mg? I know that you're not supposed to split the tablets but I'm wondering if anyone has split them , How you split that and if it was successful? LJ Friedman San Diego nov 2014
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Lavinia Fiscaletti
Hi Lj,
Although Prascend and compounded pergolide contain the same active ingredient, the formulations are different and there may be some differences in the potency. If you switch back and forth you risk pergolide veil issues on a recurring basis, if the horse is prone to that side effect. Unfortunately, as with all medications, it is an unknown how each individual will fare. As with any medication, you are generally better off choosing which formulation to use and sticking with that for consistency's sake. The Prascend is scored so you can break the caplets in halves. To give a .25mg dose, we recommend dissolving a 1/2 tablet in a small amount of water in a syringe and dosing 1/2 of the total liquid then refrigerating the rest for the next day. Repeat. For .75 mg, give 1/2 tablet and 1/2 syringe. Not convenient but doable for a few days to get to the dose you need. PPID is a progressive condition that impacts the immune system, tendons/ligaments, muscles, hair coat as well as the hooves. It will drive secondary IR that will not be controllable thru dietary management if the ACTH is not well controlled. Vaccine reactions, allergies, muscle loss, heat/cold intolerance, skin fragility, impaired wound healing, laminitis, possible seizures are some of the effects of untreated PPID. How soon, how severe is an unknown as each individual progresses at his/her own rate. How the ringbone issues will affect the horse will have a great deal to do with the trim and whether it is high or low ringbone. Once the feet are corrected, you may find that the horse is much more comfortable and stable. Xrays, if they are available, would be quite helpful in assessing this portion of the equation. Lavinia, Dante, George Too and Peanut Jan 05, RI EC Support Team ---In EquineCushings@..., <lj_friedman@...> wrote : Is it okay to switch between the two meds? For example let's say you had one month of prascend and then next month pergolide? Also if using prascend and knowing that the active ingredient is fixed and more reliable,how can you titrate starting at one quarter and working up to a full 1 mg? I know that you're not supposed to split the tablets but I'm wondering if anyone has split them , How you split that and if it was successful? LJ Friedman San Diego nov 2014 Sent from my iPhone |
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Hi LJ
I have switched one for one between Prascend and compound. You have to watch symptoms. See Pergolide 101 file and scale of symptoms in this doc: I have also cut the tablet in half. BI recommends not to cut any more than that, although members have of their own volition, because they still experienced the veil with 0.50 mg. I have not used Prascend for some time but there was a scoring mark to cut in half. Pergolide
Nancy C in NH ECIR Moderator 2003 FACT: With knowledge of the nutrient profile of the forage and the animal's weight and level of work, one can supplement only what is needed to target nutritional needs. See Smithey and Gustafson, Nutrition Complexities and Mineral Profiles of Hay 2013 NO Laminitis! Proceedings, Equine Cushing's and Insulin Resistance Group Inc.
---In EquineCushings@..., <lj_friedman@...> wrote : Is it okay to switch between the two meds? Sent from my iPhone |
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