We are two weeks into the protocol. Honey's udder is no longer swollen, eyes while still crusty a bit first thing in the morning---but not goopy throughout the day, appetite is back from veil.

My concern is her mental state, it is swinging like a pendulum.  She is, under the best of circumstances, a tad bit of a nervous Nelly and has been moved twice this month from a very stable, long term environment. i understand that the move is likely a contributing factor but even prior to the move and starting the protocol, she was exhibiting this heightened mental state.

She is uncharacteristically calm in her new paddock but quickly becomes hypervigilant and anxious when taken to other areas of the ranch.  I am trying to introduce the new environment slowly---maybe 15 mins of work in-hand outside (say in an indoor) and another 10 minutes of just walking around the ranch to familiarize her with the critters and layout of the place.  She spends the rest of the day in her paddock where she appears comfortable.

Just wondering how common this is and for those of you who have dealt with it, or are familiar with other members who have----how long did it take to subside?  She is getting 6 ml's of APF with her 1 gm Prascend.   Her hay is tested and diet is balanced.  I haven't had the water tested yet.

Thanks for all----
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Tina
4/2014  Santa Rosa, California
Honey Case History:  https://ecir.groups.io/g/CaseHistory/files/Tina%20and%20Honey  .
Photo Album:  https://ecir.groups.io/g/CaseHistory/album?id=36565  .

You're right that it's nearly impossible to tease out what might be causing what but there likely is a large component of an adjustment reaction.  Does she lie down to sleep? Was she accustomed to being alone or with a companion in the other location?

If her pergolide dose is stable you can probably start to back down the APF dose.
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Eleanor in PA

www.drkellon.com 
EC Owner 2001

Hi Tina,
I moved my barn sour, herd-bound Hanoverian from a big stable where he'd been living for 8 years to my house where he just had his long time morgan friend with him - but he can see 2 other horses next door when they are out at pasture.  He got ulcers, he dropped weight and his 'OMG I'm never going to see my friend again' reaction to me taking my morgan away from the barn (but still within sight) was extreme even 6 months after we moved.  Which is probably how he came to injure himself in his stall - tore a suspensory and is now on Reserpine so he can heal, which makes him too lethargic to be bothered fretting about little things - but possibly it's anti-psychotic effects are helping too.  He still is SUPER keen to go back to where he used to live even on Reserpine and it's been a year since we left that barn (it's only a mile away) - and he still drags his feet when I walk him back "home".  Reverse barn sour.........
Good luck
Josie
Davis CA 06/09

Thanks for getting back to me so quickly.  She does lie down to sleep.  She was previously in a herd of maybe 15 horses and honestly didn't have much of a role within the herd. She spent a fair amount of time hanging on the fringes and was pretty much ignored. 

As mentioned, she had started this hypervigilance/anxiousness prior to the move.  I passed it off as her becoming "herd bound" but now am wondering whether or not it was related to the PPID. I'm hoping it may be and that it will subside some as she becomes more balanced---it isn't any fun for either of us.

Thanks for the suggestion to start dialing back the APF.  She doesn't give me any guff when I syringe in the pergolide but clearly doesn't like the APF!
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Tina
4/2014  Santa Rosa, California
Honey Case History:  https://ecir.groups.io/g/CaseHistory/files/Tina%20and%20Honey  .
Photo Album:  https://ecir.groups.io/g/CaseHistory/album?id=36565  .

one additional point to note---her excessive sweating is a 8 or 9 on a scale of 1-10.  This is a relatively new symptom and one I don't quite know how to contend with----other than trying to bring her salt intake up.  Any suggestions?  This sweating pattern started in January of this year.

Yikes, Josie--your poor fellow...sure hope Honey settles in before she hurts herself.  Best to your boy.
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Tina
4/2014  Santa Rosa, California
Honey Case History:  https://ecir.groups.io/g/CaseHistory/files/Tina%20and%20Honey  .
Photo Album:  https://ecir.groups.io/g/CaseHistory/album?id=36565  .

Tina,

One other thing I should have mentioned is that PPID can affect vision. It would be good to get a complete eye exam, with special attention on the retina looking for any optic nerve edema.
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Eleanor in PA

www.drkellon.com 
EC Owner 2001

Dr Kellon,

I think you're on to something here.  When I had the vet out to do the TRH stim test---I asked her to look at Honey's eyes---her right in particular.  I felt as though her heightened or anxious state may in part be due to something going on with her vision.  She was disconcerted when I led her from her right side and would spook (in place) more often with stimuli from her right side. 

The vet did not observe any abnormalities in the left eye, she did see a very small "cloudiness" ( I do not recall her description verbatim) in the right eye but said it was unremarkable.  Honey had normal reflexes and pressure.

Maybe 5 minutes before your latest email came through, I was discussing with the vet (I work in the office) that I still felt some of her behavior had to do with her vision---she suggested trying one of the fly masks that filters 95% of the UV light.  Then your email arrived.  I read it to her and she confirmed that she had not seen any optic nerve edema.

I ordered a mask and will give that a go.  It's definitely a mystery---but I feel as thought we are on to something!!

Thank you---really.
--
Tina
4/2014  Santa Rosa, California
Honey Case History:  https://ecir.groups.io/g/CaseHistory/files/Tina%20and%20Honey  .
Photo Album:  https://ecir.groups.io/g/CaseHistory/album?id=36565  .