Insulin wise Advice

Kelly Gilmartin

Vet prescribed insulinwise by KPP- looking for advice because as I read the files I thought I saw that reservatrol interacts with pergolide

states product has proven to reduce insulin concentrations following an OST challenge at both 60 and 75 minutes. 
active Ingredients:
leucine 2100mg
lysine 1740mg
glutamic acid 1010 mg
reservatrol 750 mg
quercetin 500mg
proline 470 mg
alanine 395 mg
glycine 250mg

Manfredi JM, Stapley ED, Nash D. Effects of a dietary supplement on insulin and adipokine concentrations in equine metabolic syndrome/insulin dysregulatiom. J Equine Vet Sci 2020:88:102930
Kelly Gilmartin/Buddy
Western Massachusetts 
member since 2019

Lorna Cane

Hi Kelly,

If you enter Insulinwise into the Search box,you will see a number of messages,by members who have used it.
It hasn't  been a total success, in their experiences.


Lorna  in Eastern  Ontario
Check out FAQ :

Kelly Gilmartin

Do we know if the reservatrol is contraindicated in a horse on Pergolide?

Kelly Gilmartin/Buddy
Western Massachusetts
member since 2019

Lavinia Fiscaletti

Hi Kelly,

There's been lots of discussion regarding Insulinwise and resveratrol. Here are a few links to get you started:

You can search the message archives for both using the Search box at the top of the page.

Per Dr. Kellon:

Most people can eliminate most or all of the special focus supplements by going back to basic diet balancing.  This is salt, flax (for omegas), vitamin E added separately and a mineral/vitamin mix to  match your hay."

Lavinia, George Too, Calvin (PPID) and Dinky (PPID/IR)
Nappi, George and Dante Over the Bridge
Jan 05, RI
Moderator ECIR

Nancy C

Hi Kelly

Also see the doc on resveratrol here.

Hope this helps.
Nancy C in NH
ECIR Moderator 2003
ECIR Group Inc. President/Treasurer  2019-2020
Join us at the 2021 NO Laminitis! Conference, August 12-15, Harrisburg, PA


Also, there is this post by Dr. Jaini.


“Resveratrol stimulates cortisol production, which in turn raises insulin:

It has diurectic properties and diuretics can be dangerous in IR/PPID as the horse already has polyuria/polydipsia.“


Martha in Vermont
ECIR Group Primary Response
July 2012 
Logo (dec. 7/20/19), Tobit(EC) and Pumpkin, Handy and Silver (EC/IR)

Martha and Logo