metformin dosage
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There are some vets using it 3 times a day but there is no good research to show this does any good. Taking metformin on an empty stomach may improve bioavailabilility but it increases risk of GI side effects in people. Horses rarely have an empty stomach.
-- Eleanor in PA www.drkellon.com
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I started my mare Dawn on metformin three weeks ago. 15 of 1000m pills twice a day. I feed 3 x a day. When my vet came to take blood and xrays after two weeks, he said she should take the metformin 30 minutes before each of the 3 meals she gets, so half again more per day. Is this correct?
Mary and Dawn -- Mary Kane Maple Valley WA 2019
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Hi, Vicky. when I used milk of magnesia, it took about 20-30 ml to dissolve that same dose of ground metformin. An important detail is to check insulin labs again quickly, within a week if you can manage. Not all equines respond to metformin. No reason to continue syringing it twice a day if it doesn’t reduce insulin.
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Is this something he will need indefinitely, or until the insulin comes back down? He is super sensitive with any changes in diet, hay, medications, supplements, is there anything else to add with the metformin other than milk of magnesia? How much of milk of magnesia does he need? He is also currently on omeprozole due to GI upset and diarrhea lately.
-- Vicky Monen and Samson Aug 2015, Alpharetta Ga. https://ecir.groups.io/g/CaseHistory/album?id=1226 https://ecir.groups.io/g/CaseHistory/files/Vicky%20and%20Samson
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Hi Vicky 30mg per kg of 500kg bodyweight = 15,000mg. Twice daily. Canberra, Australia 2010 https://ecir.groups.io/g/CaseHistory/files/Maxine%20and%20Indy%20and%20Dangles
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Hi,
Can I ask what is the dosage for metformin for a 1000lb horse? My vet gave me the following prescription and it sounds like alot to me. my vet "He’ll get 30 (500mg) tablets twice daily for 30 days. I put in 6 refills" Under the metformin info under the files here, it suggests "The Metformin dose in horses is 30 mg/kg, twice daily, for a total of 60 mg/kg/day. After one week, retest insulin and glucose." I just got his newest labs back and his Insulin is steadily increasing. It is now at ACTH Baseline Equine 8.53 pg/mL 2 - 35 Insulin Baseline Equine 91.26 uIU/ml 10 - 40
-- I obviously have to add the metformin as his diet is very tight. No grass, weighed low starch and sugar hay in ultra slow feed nets, rationed out 4 feedings through the day. He has lost weight and definitely looks thinner than ever. Hay is at 4.7% for the past few months now new hay is 5.2%. Prascend is at 2 mg per day at 1 xday. I will add the metformin in hopes that it will help with the insulin. Is this something he will need indefinitely, or until the insulin comes back down? He is super sensitive with any changes in diet, hay, medications, supplements, is there anything else to add with the metformin other than milk of magnesia? How much of milk of magnesia does he need? He is also currently on omeprozole due to GI upset and diarrhea lately. Currently he shows no outward signs or symptoms that his pracend is not sufficient. Thank you for any suggestions. Vicky Monen and Samson Aug 2015, Alpharetta Ga. https://ecir.groups.io/g/CaseHistory/album?id=1226 https://ecir.groups.io/g/CaseHistory/files/Vicky%20and%20Samson
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