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Pergolide Stability Concerns related to Shipping Temperatures
larkstabatha
Ditto Alisa!
-- Sally in Big Park, Arizona/April 2013 https://ecir.groups.io/g/CaseHistory/files/Sally%20with%20Tabby%20and%20Maisie
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Thank you Dr. Kellon, others and Sally. The consensus seems to be that heat, followed by moisture, are the greater concerns. It appears safe to store small quantities of pergolide capsules in the door of my barn fridge (I do have one, I was just concerned that anything cold enough to safely keep my beet pulp cool would be too cold for my pills). I will incorporate into my rx order the additional request to wrap the pill bottle in some sort of insulating layer to protect it from the ice packs, and may also follow Sally and Dawn's suggestion to look into closer pharmacies like MixLab. And I will look into purchasing that neat little cooler/warmer unit that Dr. Kellon recomended--never knew there was such a thing! It would be perfect for storing just medicines at an ideal constant temp. I started reading the storage requirements on banamine, bute, wormers, arnica gel and other things I commonly keep in the TR, and they are heat/cold sensitive as well and shouldn't be stored for long periods in the fridge, so that little unit would be a perfect solution! Love this group.
-- Alisa and Andante
San Diego County, CA 1/2014
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I agree to ship with an ice pack when there is extreme heat. Either the drugs or the pack can be wrapped with cloth or several layers of paper to keep things cool but not frozen.
A mini refrigerator costs less than $40 and this one also can keep things warmer in cold weather https://www.amazon.com/Living-Enrichment-TMF-4R-Black-Thermoelectric-Medications/dp/B08G5575X6/ref=sr_1_1_sspa?crid=URQZK19SRJRP&keywords=small%2Brefrigerator&qid=1662650202&sprefix=small%2Brefrigerator%2Caps%2C85&sr=8-1-spons&th=1 . -- Eleanor in PA www.drkellon.com |
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Sherry Morse
Until Dr. Kellon can weigh in, in our collective experience you're better shipping with ice packs than not in extreme temperatures. As far as what to do if you board - I haven't ever boarded at a barn that didn't have at least a dorm sized fridge for medications although I'm sure they exist. In that case I'd be asking the barn owner to work with me as far as medication storage assuming that there is somebody with a refrigerator living on the property somewhere.
Thanks, Sherry and Scutch (and Scarlet over the bridge) EC Primary Response PA 2014 https://ecir.groups.io/g/CaseHistory/files/Sherry%20and%20Scutch_Scarlet https://ecir.groups.io/g/CaseHistory/album?id=78891 |
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Sally, thanks for raising this again. It has been sticking in the back of my mind. After the last thread on this, I did some searching on the site and ran across a recommendation (which I did not bookmark or write down) by a moderator to store pergolide capsules in the refrigerator, preferably in the door, put in an opaque bottle and protect from moisture. I have always kept it in the coolest spot in the barn (a shady feed room, buried down inside my barrel of tim. pellets), except when the temp inside seems like it'll get above high 70's in the feed room. Then I will bring home during heatwaves or put into a cooler at the barn, which is what I've done during the triple digit temps we've had the past 8 days. But after reading that post, I went ahead and moved my capsules to the door of the fridge. I added cotton balls to the RX bottle for insulation, and placed it inside of a small tupperware type container for (hopefully) additional protection. I also placed a small silica packet from another RX inside the bottle to help reduce any moisture.
Although I like the idea of overnight shipping and may look into MixLab per Dawn's suggestion, it seems to me that even if an RX goes overnight it could still be subject to extreme temperatures for 24 hours if not kept chilled or insulated. This is definitely an issue shipping from AZ (Avrio) to where I live in CA. As for condensation moisture per Martha's comment, Avrio puts the RX bottle inside of a zippered plastic bag, so hopefully this protects from any condensation coming off of the ice packs. And hopefully adding a silica packet to both the new RX bottle and the bottle with the 6-day supply that I keep at the barn will fend off moisture. So two questions remain (and maybe there is no perfect answer to either): what's the safest way to ship compounded pergolide capsules during extreme weather, and what's the best way to store them during extreme weather for those of us who board our horses and can't walk a single pill down from the temp-controlled house each day? -- Alisa and Andante
San Diego County, CA 1/2014
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I don’t know for sure, Sally, but heat generally speeds up chemical reactions and cold slows them down. I would think heat would be more of an issue than cold. Is it possible that they might make weekly deliveries to your area?
I should add that moisture is possibly pergolide’s worst enemy so if it’s shipped with freezer packs, protect it from condensation moisture. -- Martha in Vermont
ECIR Group Primary Response July 2012
Logo (dec. 7/20/19), Tobit(EC) and Pumpkin, Handy and Silver (EC/IR)
Martha and Logo |
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celestinefarm
Sally, I"m not a moderator, but having purchased compounded pergolide for years for Tipperary from various compounding phamacies, I can say that all of them, with the exception of Thriving Pets, recommended keeping the pergolide capsules in a room temperature environment. Prascend's package simply says to store below 77 degrees F. If you are using capsules, and order from an online compounding pharmacy, the having them delivered overnight is a safer way to go.
Mixlab's website says they ship overnight for free. Unless you have a compounding pharmacy within driving distance, I would recommend using the overnight delivery service from whomever you order from. Yes, it's more expensive, but better than sitting in a mail truck for a week in the heat. Dawn Wagstaff and Tipperary Saline, MI 2003 Tipperary Case History |
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larkstabatha
Hello... Hoping to go back to a question raised by several of us a few days ago. Is it understood if shipping compounded Pergolide capsules on frozen ice packs can be equally as detrimental as a shipment getting too hot in transport?
If an ECIR Moderator would kindly respond... if not just to tell us that "we don't know for sure what is least problematic for Pergolide stability in Transit... Too hot or Too cold". Hoping for a better understanding to protect the money invested in obtaining and shipping the medication, and wanting it to be as effective as possible for my horse and donkey. Thanks in advance. Best, Sally Sally in Big Park, Arizona/April 2013 https://ecir.groups.io/g/CaseHistory/files/Sally%20with%20Tabby%20and%20Maisie
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