Date
1 - 6 of 6
Wedgewood Compounded Pergolide Question
|
Stacey Smith-Bohn
My vet has agreed to provide a prescription for compounded pergolide through Wedgewood Pharmacy. My horse is currently taking 2.5 Prascend aday, and through this group it is my understanding that it is not the same, and I think we are supposed to multiply by 1.3 to convert so we would be looking at about 3.25mg pergolid??? My vet said that she has never heard of compounded being less strong than prascend as it is the same active ingredient. Wedgewood sells a compounded capsule of 3.5 mg pergolide which my vet has given me a prescription for, but I want to make sure that I have the above information right and that I would not be accidentally upping my horse's medication by a full mg!!!!
Stacey Smith-Bohn, New Jersey, 2021 https://ecir.groups.io/g/CaseHistory/files/Stacey%20and%20Terry https://ecir.groups.io/g/CaseHistory/album?id=261301 |
|
|
|
You're correct, Stacey. You need a compounded that is equivalent to 3.5 mg of PERGOLIDE BASE, not pergolide mesylate. We have confirmed with BI that Prascend dosage is based on pergolide base. The confusion comes in because the compounding recommendations talk about pergolide mesylate, not pergolide base. Your vet should call Wedgewood and specify the prescription is for 3.5 mg of pergolide base from pergolide mesylate.
-- Eleanor in PA www.drkellon.com |
|
|
|
Stacey Smith-Bohn
The pharmacist at Wedgewood said that they are compounding pergolide mesylate and the Prascend information states that each tablet contains1 mg pergolide, as pergolide mesylate, so my vet says that they are the same.
-- Stacey Smith-Bohn, New Jersey, 2021 https://ecir.groups.io/g/CaseHistory/files/Stacey%20and%20Terry https://ecir.groups.io/g/CaseHistory/album?id=261301 |
|
|
|
The drug they are using, pergolide mesylate, is the same but the compounded version isn't necessarily measuring pergolide base but rather pergolide mesylate. That is not the same thing. The 1.3 factor is to compensate for the weight in the compounded product being pergolide mesylate, not pergolide base. Your prescription has to specify 3.5 mg of pergolide from pergolide mesylate.
-- Eleanor in PA www.drkellon.com |
|
|
|
The problem comes in from the USP monograph that compounders use which specifies pergolide mesylate - e..g 1 mg = 1 mg of pergolide mesylate - but Prascend 1 mg is 1 mg of pergolide base, not pergolide mesylate.
-- Eleanor in PA www.drkellon.com |
|
|
|
Stacey Smith-Bohn
thank you
-- Stacey Smith-Bohn, New Jersey, 2021 https://ecir.groups.io/g/CaseHistory/files/Stacey%20and%20Terry https://ecir.groups.io/g/CaseHistory/album?id=261301 |
|
|