Hi, Erica.
You didn't mention if Windy experienced the pergolide veil when you started Prascend. Not knowing that, I would gradually titrate Windy's Prascend dose back up using the usual protocol suggested here: ¼ Prascend for several days, then ½ Prascend for several days, then ¾ Prascend for several days, finally 1 full Prascend.
Details in Files:
 https://ecir.groups.io/g/main/files/3%20Cushings%20Disease%20-%20PPID/Cushings%20Disease%20Treatments/Pergolide/Pergolide%20101.pdf

May I ask you to stop quoting earlier posts in your replies? It makes your posts unnecessarily long while also hiding your automatic signature. Volunteers need to find your CH to answer your questions. That's the reason it's linked in your signature attached to all posts to the forum. You can specify who you're responding to by including their name in a greeting, as I did with, "Hi, Erica."

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Cass, Sonoma Co., CA 2012
ECIR Group Moderator
Cayuse and Diamond Case History Folder                
Cayuse Photos                Diamond Photos

Yes I did but thinking I went right back to 1 tablet Prascend and should I have tapered up?

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Yes, it could, and  I hope you started her back up as soon as the blood test was done.  The diarrhea isn't necessarily related but you will find out if it is when you put her back on.
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Eleanor in PA

www.drkellon.com 
EC Owner 2001
The first step to wisdom is "I don't know."

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Erica Busch PA 2022
https://ecir.groups.io/g/CaseHistory/files/Windy%20Case%20History

Yes, it could, and  I hope you started her back up as soon as the blood test was done.  The diarrhea isn't necessarily related but you will find out if it is when you put her back on.
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Eleanor in PA

www.drkellon.com 
EC Owner 2001
The first step to wisdom is "I don't know."

Dr Dr Kellon,

Windy was off Prascend for the past 3 weeks.  Her condition has slowly declined so that by yesterday when I rode her she seemed lame, very stiff and short strided.   Today she has very bad diarrhea and pulses in the hind feet.  Vet came yesterday for blood test (She was very annoyed at me for taking her off the Prascend) Could 3 weeks off the medication affected her so? 

Sincerely, Erica

Thanks Erica

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That's good news! Yes, keep up what you are doing.  ALCar every day; Karo only after working.

Eleanor in PA

www.drkellon.com  BOGO 2 for 1 Course Sale Through End of January
EC Owner 2001
The first step to wisdom is "I don't know."

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Erica Busch PA 2022
https://ecir.groups.io/g/CaseHistory/files/Windy%20Case%20History

That's good news! Yes, keep up what you are doing.  ALCar every day; Karo only after working.

Eleanor in PA

www.drkellon.com  BOGO 2 for 1 Course Sale Through End of January
EC Owner 2001
The first step to wisdom is "I don't know."

Thank you for the input.  She is off the Prascend  staring tomorrow (1/23/23) and my vet is coming in 3 weeks.  I will upload blood results then. 

She has been more supple and not tiring a bit less up steep hills (> 25 % grades) since using ALCAR and dosing with Caro after exercise.  Her hind end muscles are like a rump roast all the time.  I live in an area with some pretty steep grades.   Thankfully  this winter has been mild and daily exercise has been possible with long warm up and cool downs.

I’ve owned horses for over 50 years and there is something definitely wrong with the abilty of the hills with this mare. I questioned my vet over the last 10 years when I got this horse without any answers.

I thank you and everyone for this group.  You are dedicated and concerned and I appreciate it much.

Erica and Windy

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Erica Busch PA 2022
https://ecir.groups.io/g/CaseHistory/files/Windy%20Case%20History

Contact Dr. Gustafson privately. Yes, messages to the group need your information but that will be added automatically if you have put it into your subscription. Fine to give ALCar twice a day. I would stick with the Karo but you can try putting it in a bowl or her feed tube to lick up.
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Eleanor in PA

www.drkellon.com  BOGO 2 for 1 Course Sale Through End of January
EC Owner 2001
The first step to wisdom is "I don't know."

Erica,

When you get a message from the group in the e-mail your reply will go to the group whether you hit reply as you would for any e-mail or if you choose view and reply online.

Windy's response to TRH was so high I suspect she would test positive any time but the question is what does "positive" mean. Does it mean she has hypertrophy but is not putting out abnormal hormone levels or does it mean she is putting out abnormal levels just not enough ACTH to test abnormal at baseline yet. We don't know. Either way it's probably a good idea to give the Prascend to control it.

With as low as her insulin was before you began Prascend I doubt there's much risk of laminitis if you stop it for a while. You can do a quick wean of half dose for a week then off, retest 3 weeks after off.

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Eleanor in PA

www.drkellon.com  BOGO 2 for 1 Course Sale Through End of January
EC Owner 2001
The first step to wisdom is "I don't know."

Hi Erica,
Your question to me was addressed by Sherry and my response would be the same - unreliable test results.  That makes 3 of us, or maybe 2.5, depending on who commented first.

As a volunteer in the ECIR group, I’m not trained to assess muscle disease, but there are groups which are.  Hoping someone will step up and direct you there.  Is the Alcar helping with the issues which you mentioned in your first post?

If you can avoid quoting the post you’re speaking to, that would be helpful for us.  You don’t post enough to make it difficult to follow (yet) but the quoted material can complicate our reading.  Which aspect of updating your case history do you find the most difficult?  I’d be glad to help.  I know the new form will be available at some point but you are here now, looking for help.
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