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L-Carnitine- Alcar

Shera Felde #286023 Thank you both! I ordered AAKG and acetyl-l-carnitine thinking about preventing winter laminitis, and then i started to get confused:) -- Shera Felde, Central Oregon, 2020 https://ecir.groups.io/g/CaseHistory/files/Story%20and%20Shera https://ecir.groups.io/g/CaseHistory/album?id=253720
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Eleanor Kellon, VMD #286018 Nancy just brought up another use for L-carnitine. When on Invokana and losing glucose, the body must metabolize fats effectively. L-carnitine is needed to carry fatty acid liberated from triglycerides into the mitochondria to be burned. It's not a fix by itself for high triglycerides but can help. -- Eleanor in PA www.drkellon.com EC Owner 2001 The first step to wisdom is "I don't know."
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Eleanor Kellon, VMD #286016 ALCAR (acetyl-l-carnitine is a metabolite of L-carnitine. When you feed either one the body will do the interconversions to some extent but if you feed L-carnitine you will end up with more L-carnitine and vice versa. L-carnitine is fed to improve the metabolism of fats. ALCAR is effective in relieving neuropathic pain in laminitis, helps with nerve regeneration, improves mitochondrial numbers and encourages glucose into energy burning pathways. In humans, it works with metformin in alleviating IR in women with PCOS https://pubmed.ncbi.nlm.nih.gov/34047916/ . In this study, L-carnitine also improved metabolics in IR individuals and increased ALCAR https://pubmed.ncbi.nlm.nih.gov/31676389/ .This study using more advanced type 2 diabetes patients found no response https://pubmed.ncbi.nlm.nih.gov/29696241/ . Either one certainly won't hurt with EMS but the major application here is neuropathic hoof pain. -- Eleanor in PA www.drkellon.com EC Owner 2001 The first step to wisdom is "I don't know."
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Nancy C #286015 OK, Shera. I am still learning too. I believe L-Carnitine is recommended for Invokana horses where triglycerides are an issue. Your vet needs to be on board with Dr K. Acytel_L-Carntine is most often used here for neuropathic pain in winter laminitis and general neuropathy. Dr Kellon, please correct me if I don't have this right. -- Nancy C in NH ECIR Moderator 2003 ECIR Group Inc. President 2021-2022 HOW TO SEARCH THE ARCHIVES: https://ecir.groups.io/g/main/wiki/1993
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Shera Felde #286012 Thanks, Nancy. I seem to recall Dr. Kellon distinguishing between the two for different purposes (maybe I have the names wrong?) -- Shera Felde, Central Oregon, 2020 https://ecir.groups.io/g/CaseHistory/files/Story%20and%20Shera https://ecir.groups.io/g/CaseHistory/album?id=253720
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Nancy C #286007 Hi Shera While you are waiting for Dr Kellon, here's folder with several article on ALCAR. ALCAR is acetyl-L-carnitine. https://ecir.groups.io/g/main/files/Acetyl-L-Carnitine More in the archives such as.... https://ecir.groups.io/g/main/topic/93680794#283232 -- Nancy C in NH ECIR Moderator 2003 ECIR Group Inc. President 2021-2022 HOW TO SEARCH THE ARCHIVES: https://ecir.groups.io/g/main/wiki/1993
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Shera Felde #286004 Dr. Kellon, Would you please explain the difference (use and effect) of acetyl L carnitine and L carnitine (alcar?)? thank you, -- Shera Felde, Central Oregon, 2020 https://ecir.groups.io/g/CaseHistory/files/Story%20and%20Shera https://ecir.groups.io/g/CaseHistory/album?id=253720
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