HI, I saw an alleviation of symptoms within 2 months of starting the permax. Definite difference in hair growth! We had the urination and drinking already under control. Improvement in attitude too. But the biggest recognizable difference has been since we started the Thyrol! I haven't seen my mares eyes this bright and her attitude this sweet in years! What a wonderful effect! I love to see her face staring at me when I come into the barn. Melts my heart everyday!! Chris in CA