Adjusting pergolide when rise ends


riggslippert@...
 

Hello,

My case histories are updated.  I increased pergolide for both Cadet and Ruger on 8/23/22 in response to ACTH levels run on 8/17/22.

Cadet ACTH 27.9 pg/mL (2-30), increased from 3.0 mg QD to 3.5 mg QD
Ruger ACTH 34.7 pg/mL (2-30), increased from 4.0 mg QD to 4.5 mg QD

Both horses are currently receiving a combination of compounded pergolide and Prascend.  Both horses are doing well clinically, although both drink and urinate excessively.  For Cadet, I know this is probably because he is on Invokana.  For Ruger, this is really the only clinical sign of PPID he is showing at this time.

My question regards what to do with their pergolide dosages when the rise is over.  I am leaning towards decreasing them both 0.5 mg around 12/1/22 and then retesting in January of 2023.  I would appreciate any input on my plan.  As always, I am indebted to this group for its help and advice!
--
Aunna
October 2018
Island County, Washington, USA
Cadet Case History:  https://ecir.groups.io/g/CaseHistory/files/Aunna%20and%20Cadet
Ruger Case History:  https://ecir.groups.io/g/CaseHistory/files/Aunna%20and%20Ruger

Cadet Photo Album:  https://ecir.groups.io/g/CaseHistory/album?id=84102




 

Hi Aunna,
My suggestion would be to leave the doses as they are and then test and make a decision based on that.  Half a mg wasn’t a big increase for the rise.  Increased urination is a sign I monitor to decide on increasing a dose so I especially would not decrease Ruger’s.  I reflect the need for an ever increasing  pergolide dose, which is what I experienced.  If you feel that hasn’t been the case for your guys, you could back the dose off as you suggested.
--
Martha in Vermont
ECIR Group Primary Response
July 2012 
 
Logo (dec. 7/20/19), Tobit(EC) and Pumpkin, Handy and Silver (EC/IR)

Martha and Logo
 


riggslippert@...
 

Hi Martha,

Thank you for that recommendation!  I actually increased both horses by 1 mg total this year, starting in July, but I see your point, especially about Ruger.  I will keep them at this dosage as suggested.  I certainly don't want to mess with success!
--
Aunna
October 2018
Island County, Washington, USA
Cadet Case History:  https://ecir.groups.io/g/CaseHistory/files/Aunna%20and%20Cadet
Ruger Case History:  https://ecir.groups.io/g/CaseHistory/files/Aunna%20and%20Ruger

Cadet Photo Album:  https://ecir.groups.io/g/CaseHistory/album?id=84102