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Has anyone tried Cyproheptadine to help control PPID when Prascend isn’t working?
-- Vicky E, Canuso member - 2017 Location - New York/Florida |
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Hi Vicky
Cyproheptadine does not work. Increased of pergolide dose is needed to lower ACTH. https://drkhorsesense.wordpress.com/2022/04/04/nothing-new-about-cyproheptadine/ -- Nancy C in NH ECIR Moderator 2003 ECIR Group Inc. President 2021-2022 ECIR Group NEW Case History site open to Early Adopters.
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-- Thank you Nancy for getting back to me so quickly. I just recently had my 23 year old gelding’s bloodwork done. The TRH Response: ACTH - Pre 86.2 pg/ml - Post >1250.0 pg/ml Insulin - 63.48 uIU/ml Leptin - 8.28 ng/ml He is on 2 1/4 tablets of Prascend right now. Should I increase by 1/4 tablet or more? Thank you so much !!! Vicky Vicky E, Canuso member - 2017 Location - New York/Florida |
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Hi Vicky,
Please note that once a horse is positively diagnosed as PPID and is on medication there is no need to do the TRH test. Your pre-level shows that your 2.25 pills are not controlling his PPID at this point. Were he mine I'd bump him up to 3mg and test him 3 weeks after reaching that dose to see if that's brought his ACTH down to the upper teens/low 20s where we like to see it year round in a positive horse. If it doesn't you'll need to bump him up again. As that is cost prohibitive with Prascend for most people you might want to start a discussion with your vet about switching to compounded pergolide to reduce your costs.
Thanks,
Sherry and Scutch (and Scarlet over the bridge) EC Primary Response PA 2014 https://ecir.groups.io/g/CaseHistory/files/Sherry%20and%20Scutch_Scarlet https://ecir.groups.io/g/CaseHistory/album?id=78891
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