Introduction and questions


LNGERZ@...
 

Seems like my mules have had Cushings for a lot longer than most of your
horses. Weird thing is, we tested the biggest one, Sadie, first for Thyroid
problems because I was feeling her neck one 1997 June day and Voila, an
enlarged thyroid! Then we adjusted her thyroid levels, only to find out with
other testing that she had Cushings. No long wavy coat, but a late shedder.
Had the cresty neck and now has the fat deposits, like on her butt, above her
tail.

She has had one abscess during the past three years, and quite a few bouts
with what I am now calling "chronic laminitis." She has her hooves trimmed
regularly every 6 weeks, is on a good diet, with supplements, Thyrol and
liquid cyproheptadine. I am not really liking the way her feet have looked
(some separations, little old bloody spots) after her trims since I started
the liquid. Has anyone else had this problem or noticed that the liquid
doesn't seem to be as effective as the pills, (or is it in my head?)

Daisy Donkey, the "Poster Donkey Picture" of a a hypothyroid mini-donkey
tested out to be exactly that in Sept. of 1997, but strangely enough, she,
cresty neck, fat deposits all over, and tiny little hooves, is not a Cushings
Syndrome patient. She is on ThyroL only, and does very well, thank you for
asking. (Daisy is VERY polite)

Pandora Mule is aptly named, because she is a veritable "Pandora's Box" when
it comes to complications of Cushings. She was diagnosed in Nov of 97 and
don't ask me why we waited so long. She was a little less hypothyroid, but
has had so many abscesses in every hoof that I truly have lost count. She
has been to Cornell for an assessment of her condition. (She had both hind
hooves wrapped at that time, abscesses had been removed, partial hoof
resections, both hooves by my vet, then taken to Cornell for consultation)

Some days I can hardly bear to look out at Pandora, I know if it is 10 days
after trimming, and she has a limp, we will see 3-legged lame within the next
day and by Day 14, she will have had an abscess break out on her coronary
band. I am presently wrapping both Pandora and Sadie's hooves with
disposable diapers and Duct Tape. It is very wet here, they were just
trimmed last Tuesday and this seems to help cut down on Pandora's abscesses.
Sadie -- well, I am doing her just to make me feel better.

Can you tell I am a retired RN? I pass meds out here morning and night, it
seems, and yes, the only thing I hope to do with the Cyproheptadine is
control the signs/symptoms of Cushings. That is all any of us can hope for,
since there truly is no treatment that can lead to a cure.

My vet tells me that "they" are now looking into laminitis with more focus on
Cushings. It might end up being a "Which came first -- the chicken or the
egg?" thing when the studies are completed. Will I live that long? Will the
mules? Do you know that a donkey could live to be 50 or 60 years old? Yes,
my daughters are counting the days/months/years.
Kay, in NY Yep, still another Kay


LNGERZ@...
 

Jackie,
You really DO NEED to shake that med like crazy, but each time it is easier
after the initial SHAKE! If you don't do that, you are not giving the
correct dosage. Keep on Shaking and Shaking, or you will have all the "good
stuff" left in the bottom of the bottle! I know exactly what you are talking
about -- been there, done that and finally had success.
Kay, who is obsessed with these meds. Who gets what now? Oh, good
lunchtime, no one needs meds, not even the dog, who, incidentally is
hypothyroid too. And yes, on a whim and at the suggestion of an "Online Vet
-- Dr. Julie, maybe you knew her from the Horse Forum -- I had my blood
tested for thyroid levels too -- $249 later -- I am "Normal????" My husband
questions that every day, but that is another novel.

So good luck to all of us, and let's have a toast to beating or at least
controlling Cushings in our equines. Make that "well shook cyproheptadine
for me!" Kay in NY


Barbara P. <MorganPinesFarm@...>
 

Hi. My name is Barbara and I live in Va. I have a 20 year old
Andalusian mare, Amiga, whom we believe has Cushing's. I've only had
her since September but I do have a sketchy history.
When she was 10 she foundered. Her vet felt it was due to extreme
overweight, put her on a diet ( no grain) and also Thyrol-L. The main
purpose of the Thyrol was to help keep her weight down. Five years
later she went very lame but according to her owner, the vet did not
say it was laminitis per se, but an inflammation. At no time was
Cushing's even mentioned. Over the last 10 years she was off and on
the Thyrol-depending on what her blood work showed. For the last 3
years she was on it full time ( 2 scoops per day) and her weight has
been down.
When I got her she was pretty much a backyard pet, had not been
ridden for 5 or 6 years. She had a very thick coat already for Sept. (
red flags started to go up) but I thought it might be because she came
from New England and was putting on her winter coat. The other strange
thing was that even though she had lost about 400 pounds, she had
lumpy fat pockets in the strangest places. Under my vet's instruction,
we started decreasing the Thyrol-testing her every few months until we
had her down to ½ scoop per day. I had her on ABC plus as well as
Grand Flex, no grain, grass hay. I started riding her very gradually
(soft footing) until by May we were ready to try our first dressage
show. Then bang, about the middle of May she went lame. She was acting
like a foundered horse but had not heat or pulse. I had been limiting
her grass so my vet didn't feel that was the problem. When we compared
her present x-rays to those of 5 years ago there was very little
change. The only clue was that her insulin level was way high. So
based on that we started treating her as a Cushingoid horse. At some
point we will do more testing but not the dex. suppression test.
Here's where we're at right now. She was on bute until she started
walking comfortably. I just started her on devil's claw. She's
barefoot and is doing well, will trot sound and has even picked up a
canter in the field. I'm working with both a traditional vet and an
alternative one and taking the best of both. She's getting 1 scoop of
Thyrol, ABC plus, 150 mg of cyproheptadine (liquid), devil's claw
capsules, 100 mg. Co Q 10 and something called Core Level Pituitary.
She gets a tiny amount of Horse Chow wet down so she will eat all of
this. She has free choice grass hay and still limited grass until
things dry up.
These are my questions:
1. Most of you seem to use pergolide. Is it because the cypro stopped
working?
2. Do you find that your horses can't tolerate the heat? Amiga is in
most of the day with fans and I either hose her or sponge her with
alcohol/water.
3. My vet would like to keep her without shoes if possible. My pasture
is flat and fairly rock free and I had her barefoot until March when I
thought I would be taking her out to shows. What is the consensus
about shoes?
4. I've seen a lot of you mention Thyrol. I'm beginning to wonder if
lowering her dose may have triggered this latest flare up.
5. Speaking of flare ups-are there any clues to watch for or will she
just be sound one day and lame the next? Also, is there any hope of
riding her again? She was doing so well and I think was enjoying being
ridden-it gave her a purpose.
Sorry this was so long. I look forward to being a part of
these boards. It was thanks to Marie and Sue that I found them.
Barbara


LNGERZ@...
 

I also can count on the bug bites causing hives on Pandora about July 15th.
She is so darn predictable. Then she has to have an injection of an
antihistamine because she foundered her original time after Azium for that
problem. Not sure, but that seems to have triggered the whole Cushings
thing, or at least we finally realized what the heck was going on with her.

Actually, I can give you just a tiny bit of advice with your mini-donkey! DO
NOT overfeed. You will find that they can gain on almost nothing. Never
have I seen an animal gain as easily as she does, even with her thyroid
condition under control. But she is really a Houdini with the fences and is
too smart. Literally is a "Smart Ass!" Her tiny feet have had two problems
in about 9 years. She got ice in her hoof once, and when the new, young vet
came to check her out, she held perfectly still, looking in my eyes as I held
her. Unfortunately the NEW YOUNG vet, took her temp and was checking out the
location of his thermometer. Yep, WHAM, right on his cheek and never did she
get that wild eyed look that horses get, where you see the whites of their
eyes and know there is going to be trouble. She just nuzzled into my hands,
and let him have it. He was so embarrassed and I told him to tell the people
at the clinic that a Clydesdale had done it. He said that they knew they had
sent him out to check out a mini-donkey.

The second time Daisy Mae Donkey had a foot problem, she had stepped on some
nail or something. Now this could have really amounted to something with the
mules, but with Daisy -- instant lameness -- vet came -- cleaned it out, a
few days of soaks, dressings and a little vetwrap and she was cured.

I had a new harness made just for her, and she only tried it on once, never
bothered to drive her. Should have, just didn't. Had a second girth made
for Daisy too, and by the time the harness maker had it made, it was already
6" too short. See what I mean about how easy they gain? We are talking
almost ZERO feed, maybe a tablespoon am and pm for her meds, and grass hay.

Hey, this is the end of my novel on Father's Day. It is raining here again!
Kay in NY


Jackie Rice <jrice@...>
 

Regarding liquid cyproheptidine, my horse just went on it May 25. He'll be trimmed June 28th, so I'll watch for the spots you are talking about. The liquid has settled out on the bottom and I can't resuspend it for the life of me no matter how hard I shake it. So that would be my caution on the liquid. Next time I'll be sure to get a bottle that hasn't settled or use the pills.

----- Original Message -----
From: LNGERZ@...
To: EquineCushings@...
Sent: Sunday, June 18, 2000 8:01 AM
Subject: Re: [EquineCushings] Introduction and questions


Seems like my mules have had Cushings for a lot longer than most of your
horses. Weird thing is, we tested the biggest one, Sadie, first for Thyroid
problems because I was feeling her neck one 1997 June day and Voila, an
enlarged thyroid! Then we adjusted her thyroid levels, only to find out with
other testing that she had Cushings. No long wavy coat, but a late shedder.
Had the cresty neck and now has the fat deposits, like on her butt, above her
tail.

She has had one abscess during the past three years, and quite a few bouts
with what I am now calling "chronic laminitis." She has her hooves trimmed
regularly every 6 weeks, is on a good diet, with supplements, Thyrol and
liquid cyproheptadine. I am not really liking the way her feet have looked
(some separations, little old bloody spots) after her trims since I started
the liquid. Has anyone else had this problem or noticed that the liquid
doesn't seem to be as effective as the pills, (or is it in my head?)

Daisy Donkey, the "Poster Donkey Picture" of a a hypothyroid mini-donkey
tested out to be exactly that in Sept. of 1997, but strangely enough, she,
cresty neck, fat deposits all over, and tiny little hooves, is not a Cushings
Syndrome patient. She is on ThyroL only, and does very well, thank you for
asking. (Daisy is VERY polite)

Pandora Mule is aptly named, because she is a veritable "Pandora's Box" when
it comes to complications of Cushings. She was diagnosed in Nov of 97 and
don't ask me why we waited so long. She was a little less hypothyroid, but
has had so many abscesses in every hoof that I truly have lost count. She
has been to Cornell for an assessment of her condition. (She had both hind
hooves wrapped at that time, abscesses had been removed, partial hoof
resections, both hooves by my vet, then taken to Cornell for consultation)

Some days I can hardly bear to look out at Pandora, I know if it is 10 days
after trimming, and she has a limp, we will see 3-legged lame within the next
day and by Day 14, she will have had an abscess break out on her coronary
band. I am presently wrapping both Pandora and Sadie's hooves with
disposable diapers and Duct Tape. It is very wet here, they were just
trimmed last Tuesday and this seems to help cut down on Pandora's abscesses.
Sadie -- well, I am doing her just to make me feel better.

Can you tell I am a retired RN? I pass meds out here morning and night, it
seems, and yes, the only thing I hope to do with the Cyproheptadine is
control the signs/symptoms of Cushings. That is all any of us can hope for,
since there truly is no treatment that can lead to a cure.

My vet tells me that "they" are now looking into laminitis with more focus on
Cushings. It might end up being a "Which came first -- the chicken or the
egg?" thing when the studies are completed. Will I live that long? Will the
mules? Do you know that a donkey could live to be 50 or 60 years old? Yes,
my daughters are counting the days/months/years.
Kay, in NY Yep, still another Kay



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Kay Howitt <akkray@...>
 

Hi Barbara, good luck with your mare Amiga. It sounds like she has a good
home with you. I think Andalusians are very beautiful horses.

You asked a few questions...here's what applied to me and Domino. He is on
pergolide because he didn't respond at all to ciproheptadine. I don't know
how he would do in heat, as we are in Fairbanks and it hasn't yet gotten
above 80 degrees, plus Domino has been on stall rest for nearly 2 months. I
did have to blanket him extra heavily in last winter's cold (minus 40 at
lowest) and he had a hard time keeping his weight on. I would love to keep
him barefoot, but we are rocky here and he's been lame since the end of
February. My vet is using Dr. Ric Redden's therapuetic shoeing with
impression material and rail shoes. My horse has rather mild rotation, but
the coffin bone has sunk about 3 mm in both right front feet and there is an
abscess in the left. If we/he lived in a warmer climate with shorter winters
we'd have more options and more time to deal with everything. Kay in AK


Kay Howitt <akkray@...>
 

Hi Kay...great name!

My goodness, you have certainly had some bad luck with so many Cushing's cases.
It seems a weird coincidence to have several at once. I sure hope there's
research going on about Cushing's, as it is a difficult and puzzling syndrome.

I suspect Domino has had Cushing's for more than the past three years, but
there's no way to know. About 7 years ago he had surgery to remove a large shoe
boil and it took him 7 months to heal the surgical wound and the abscess that
developed in a front foot. Those complications sound awfully like they were
Cushing's related to me. Last year he had a second surgery to remove a new shoe
boil (had not been able to prevent it despite every kind of protective device you
could imagine.) Again the wound wouldn't heal and he developed a full blown case
of laminitis. In my heart I believe he's had Cushing's for at least 7 years (age
15 or 16).

I'll be getting a miniature donkey this summer and keeping my fingers crossed
neither she nor my Icelandic gelding ever, ever develop Cushing's. Kay in AK