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Salt and insulin resistance
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Chatycady@...
Does salt play a role in correcting insulin imbalance in some IR horses? And/ or does appropriate salt intake help maintain a proper insulin response?
-- Chatycady in the Midwest 2022 CaseHistory@ECIR.groups.io | Files |
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Salt is not involved in the insulin response. It is an indispensable part of a healthy diet and critical to maintaining hydration.
-- Eleanor in PA www.drkellon.com |
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On Sun, Nov 13, 2022 at 08:23 PM, Eleanor Kellon, VMD wrote:
Salt is not involved in the insulin response. It is an indispensable part of a healthy diet and critical to maintaining hydration.I learned from our WikiKellon, that is also takes part in non insulin dependant pathways of glucose incorporation into cells, like exercise. Sodium is needed to introduce glucose into cells via sodium-potassium channels, so good levels of sodium are an indirect help to reduce blood glucose levels and reduce insulin stimulation to clear that glucose from blood. Also needed to absorb glucose and aminoacids in the gut and neuromuscular work. -- María Durán Navarro Dec 2017 Madrid (Spain) Plutón´s Case History Plutón´s Photo Album _._,_._,_ |
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HI Maria
Having a senior moment. What and where is "our WikiKellon"? Thanks -- Nancy C in NH ECIR Moderator 2003 ECIR Group Inc. President 2021-2022 HOW TO SEARCH THE ARCHIVES: https://ecir.groups.io/g/main/wiki/1993 |
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Sorry Nancy,
Only an affectionate name for the wonderful kowledge Dr. Kellon has and provides us with. She is like an specialized Wikipedia for nutrition and veterinarian research. I have a section in my files called like this with Dr. Kellon's special pearls of knowledge from the courses. -- María Durán Navarro Dec 2017 Madrid (Spain) Plutón´s Case History Plutón´s Photo Album _._,_._,_ |
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OK. thanks Maria. Now my senior brain needs to knit your quote to what Dr Kellon said:
You said: good levels of sodium are an indirect help to reduce blood glucose levels and reduce insulin stimulation versus Dr K said: Salt is not involved in the insulin response And, versus the quote in the OP does appropriate salt intake help maintain a proper insulin response? EDITED: Sorry, hit send by mistake. Dr Kellon, could you please clarify? Can sodium lower insulin through faster glucose transport? it is affecting glucose and therefore "not involved in insulin response"? Thanks -- Nancy C in NH ECIR Moderator 2003 ECIR Group Inc. President 2021-2022 HOW TO SEARCH THE ARCHIVES: https://ecir.groups.io/g/main/wiki/1993 |
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Oh sorry Nancy, I didn't mean to say it is of help to lower insulin as a treatment. That sentence was linked to this one "I learned from our WikiKellon, that is also takes part in non insulin dependant pathways of glucose incorporation into cells, like exercise." Exercise improves glucose uptake by sodium channels and less glucose levels in blood lead to less insulin needed to lower that glucose already taken by muscle cells. That's why exercise helps so much IR horses. For that, sodium is needed. That was all what I meant to say. Sorry if I mislead someone and sorry for the weird format -- María Durán Navarro Dec 2017 Madrid (Spain) Plutón´s Case History Plutón´s Photo Album _._,_._,_ |
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Salt is involved in the uptake of glucose by intestinal cells, not the uptake of glucose by cells in the body. Inside the body, cells uptake glucose via glucose receptors, the GLUT transporter family of which there are at least 14. GLUT4 is the insulin sensitive glucose transporter.
-- Eleanor in PA www.drkellon.com |
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Dr. Kellon,
I have this from you to a question about muscle cell uptake in the CIR course "There are also sodium-glucose cotransporters which carry both sodium and glucose into the cell. The sodium is then pumped back out."
To my understanding there are also SGLT (sodium-glucose transporters) in the muscle cell that need sodium for glucose uptake. Am I wrong?
I have even searched for it as it made me doubt and found many studies talking about sodium-glucose transporters in the muscle cell, this is only one of these:
It says " Glucose transport proteins are divided in two groups: glucose facilitated transporters (GLUT) and sodium dependent D-glucose co-transporters (SGLT). GLUT allows transport of glucose down its concentration gradient, while SGLT transports glucose against its concentration gradient."
"The sodium-dependent D-glucose co-transport system is mainly expressed in skeletal muscle"
If I understood correctly these sodium dependant trasporters for glucose are from the SGLT family being the one in the muscle the SGLT3, is this wrong?
-- María Durán Navarro Dec 2017 Madrid (Spain) Plutón´s Case History Plutón´s Photo Album _._,_._,_ |
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The SGLT glucose transporter system is activated by exercise https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475428/ . Activation of this system may explain the beneficial effects of exercise on insulin resistance. At maintenance, it has little effect. In any case, dietary salt/sodium will not affect this as the body places high priority on maintaining blood sodium levels.
-- Eleanor in PA www.drkellon.com |
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Chatycady@...
In cowgirl terms - A healthy hydrated horse will have energy and will tolerate more exercise, and exercise controls insulin levels. Correct? I have a more "energetic" herd since adding salt to their diets. All are senior citizens. Thank you!
-- Chatycady in the Midwest 2022 CaseHistory@ECIR.groups.io | Files |
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Thank you Dr. Kellon,
Yes I understand, of course sodium does not influence the activity of SGLT, only that they requiere sodium. I guess at extreme deficient dietary sodium, it is released from bone to keep good blood levels. Thank you -- María Durán Navarro Dec 2017 Madrid (Spain) Plutón´s Case History Plutón´s Photo Album _._,_._,_ |
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Chatycady,
Yes, that's correct. Insufficient salt is the #1 cause of poor performance/poor endurance in the heat. -- Eleanor in PA www.drkellon.com |
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